Sign up | Log in



Home  >>   Daily News  >>   Singapore  News  >>   Health Business  >>   Singapore stem cell breakthrough
NEWS UPDATES Asean Affairs   18 October 2010

Singapore stem cell breakthrough

Related Stories

July 2, 2010
Singapore transfers hospital to Indonesia

June 15, 2010
U.S.Japanese bring Cambodia aid

May 1, 2008
State firm to raise stake in Parkway

March 21, 2008
New hospital for affluent clients unveiled

A Singapore team of researchers has discovered the most important genes in human embryonic stem cells (hESCs), a crucial breakthrough in discovering how human stem cells work.

The team's research offers crucial understanding on how stem cells may one day be used to treat debilitating conditions such as Parkinson's disease and traumatic spinal injury.

The team comprises scientists from the Genome Institute of Singapore (GIS) and the Institute of Molecular and Cell Biology (IMCB), which are two biomedical research institutes of Singapore's Agency of Science, Technology and Research (A*STAR).

The scientists investigated the 21,000 genes in the entire human genome to find those which regulate the two characteristic properties human embryonic stem cells: The capacity to turn into any type of cell in the human body or what's known as pluripotency, and the ability to retain that capacity indefinitely.

Out of the several key genes they identified, a particular gene known as PRDM14 was discovered to make it easier to turn a type of human cell into pluripotent stem cells.

Their research, published in top scientific journal Nature, is the first genome-wide study of human stem cells on such a massive scale.

The discoveries contribute to a fundamental understanding of the nature of stem cells and help efforts to improve techniques to turn mature adult cells into hESCs.

In addition, the scientists found PRDM14 played a key role in hESCs, but not in mouse ESCs.

This significant new finding highlights the fundamental differences between stem cells from different species, and highlights the greater need to use human cells in stem cell research.

GIS senior group leader for Stem Cell and Development Biology and associate director for Biology Ng Huck Hui said: "Very little is known about the molecular machines that drive stem cell states or the transcriptional profiles of hESCs.

"Our study helps to build a better understanding of hESCs and this will help in the development of technologies to further the utilities of these cells such as their potential to be used for clinical and therapeutic applications".

Reach Southeast Asia!
10- Nations, 560- Million Consumers
And $1 -Trillion Market
We are the Voice of Southeast Asia Media Kit
The only Media Dedicated to Southeast Asia Advertising Rates for Magazine
  Online Ad Rates

Comment on this Article. Send them to

Letters that do not contain full contact information cannot be published.
Letters become the property of AseanAffairs and may be republished in any format.
They typically run 150 words or less and may be edited
submit your comment in the box below




1.  Verifier

1. Verifier

For security purposes, we ask that you enter the security code that is shown in the graphic. Please enter the code exactly as it is shown in the graphic.
Your Code
Enter Code

Home | About Us | Contact Us | Special Feature | Features | News | Magazine | Events | TV | Press Release | Advertise With us

| Terms of Use | Site Map | Privacy Policy  | DISCLAIMER |

Version 5.0
Copyright © 2006-2020 TIME INTERNATIONAL MANAGEMENT ENTERPRISES CO., LTD. All rights reserved.
Bangkok, Thailand